Mice may be teaching us about the genetic basis of bipolar disorder. This mood disorder, which is often called by its older name, manic-depressive illness, is characterized by wide mood swings that range from high (manic) to low (depressed). Scientists, who published their research in the April 10 issue of the Proceedings of the National Academy of Science (PNAS), studied mice that have a variation or mutation in a gene called the Clock gene. The Clock gene helps regulate the body’s daily circadian rhythm — the ups and downs of biological functions that occur over a 24-hour period. Mice with this variant gene show signs similar to human mania. When […]
